Jennie K. Daniels
Organic and natural Chemistry 2121
11 Feb . 2014
Activity of Acetylsalicylsaure
Salicylic acid solution derivatives, or salicin, are found in the bark of the willow tree. In the 5th hundred years B. C., Hippocrates floor the bark into a powdered, and later, the Natives People in the usa chewed within the bark to ease fever and pain1. Inside the 19th century, a German born chemist named Felix Hoffman wanted to discover a medication that would ease his father's arthritis without leading to irritation to his belly. The standard osteoarthritis medication at the time, sodium salicylate, could not always be tolerated by many people patients, Hoffman's father included, due to the soreness of the abdomen lining brought and by large doses 2, Hoffman produced acetylsalicylic acid solution ‘through a lot of chemical reactions that covered in the acidic portions with a great acetyl group' 3, and was found to alleviate fever, minor pain, and arthritis pain at larger doses. In 1899, the Bayer firm sold acetylsalicylsaure for the first time from the commercial perspective in Germany and in the United States in 1900 5.
In recent times, it has been proven that aspirin helps prevent heart problems in sufferers with heart disease and in healthful men older than 50. To prevent a myocardial infarction, low medication dosage aspirin (81-325mg) is used. Within a heart attack, a 325mg, non-coated aspirin tablet must be wrecked to prevent bloodstream platelets by clotting. The tablet should be uncoated because of the aspirin operating slow, and the tablet has to be chewed for the reason that healing reactions are fastest with this approach (14 mins chewed vs . 26 a few minutes swallowed) five.
The purpose of synthesizing aspirin, other than to discover a less intestinal irritating pain reliever is always to determine if the experiment works using current methodology and to determine the resulting compound's purity by obtaining the burning point 6. Aspirin is a frequent medication for reducing fever, aches, and pains....
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